Mechanically tunable, self-adjuvanting nanoengineered polypeptide particles

J Cui; R De Rose; JP Best; APR Johnston; S Alcantara; K Liang; GK Such; SJ Kent; F Caruso

Journal article

Mechanically tunable, self-adjuvanting nanoengineered polypeptide particles

J Cui, R De Rose, JP Best, APR Johnston, S Alcantara, K Liang, GK Such, SJ Kent, F Caruso

Advanced Materials | Published : 2013

DOI: 10.1002/adma.201300981

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Abstract

DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

University of Melbourne Researchers

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Grants

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Australian Research Council Super Science Fellowship

Awarded by NHMRC Career Development Fellowship

Funding Acknowledgements

This work was supported by the Australian Research Council under the Australian Laureate Fellowship (F. C., 120100030) and Discovery Project (F. C., 130101846) schemes, and by the National Health and Medical Research Council (NHMRC) program (S.J.K., 510448) and fellowship awards (S.J.K., 508937) awards. J.C. is the recipient of an Australian Research Council Super Science Fellowship (FS110200025). J.C. also acknowledges the support of the Early Career Research Grant from the University of Melbourne. R. D. is supported by the NHMRC Career Development Fellowship (APP1011578). A.P.R.J. acknowledges the support of an ARC Future Fellowship. Dehong Chen is thanked for the nitrogen sorption experiments.